MECHANISMS OF ATTENUATION OF COLD-ADAPTED STRAIN A/KRASNODAR/101/35/59 (H2N2)
نویسندگان
چکیده
منابع مشابه
Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus.
The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca v...
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We previously reported that the A/Leningrad/134/47/57 (H2N2) cold-adapted virus (A/Len/47) used in preparing reassortant live attenuated vaccines for children acquired 14 (11 coding) mutations in genes coding for proteins other than haemagglutinin and neuraminidase during cold-adaptation. Preservation of these mutations in genomes of viruses isolated from children on the second, fifth, or eight...
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ژورنال
عنوان ژورنال: Journal of microbiology, epidemiology and immunobiology
سال: 2016
ISSN: 2686-7613,0372-9311
DOI: 10.36233/0372-9311-2016-2-49-56